2022年6月21日星期二

Webinar: Solving API Manufacturing Challenges with Flexible Containment

 Webinar named “Solving API Manufacturing Challenges with Flexible Containment” was organized by ILC Dover. This webinar discussed some of the common challenges faced in handling powders during HAPI/API manufacturing. Key strategies to mitigate risks associated with these issues was shared including how flexible containment solutions can optimize powder handling during chemical synthesis. Ms. Kayla Hager was the guest speaker.


Firstly, she introduced the whole process of chemical synthesis of Active Pharmaceutical Ingredients (APIs) from “Materials arrive” to “Pack off to oral solid dosage process”.


Then she briefed some common challenges including powder containment and dust mitigation, operational efficiency, sustainability and others.


Some controls for the contain at the source include “Control of the environment”, “Reduce airborne particulate”, “Protect operators”, “Reduce risk of cross contamination” and “Consider ergonomic”. Some steps of chemical synthesis under contain at the source showed as following diagram.


An intermediate bulk container (IBC) is a pallet mounted, industrial grade reusable container that is used for storing and transporting bulk liquids and powders. Cleaning IBC’s and Disposal of Flexible intermediate bulk containers (FIBC) were then discussed.


Ms.Hager said disposal of FIBC is more sustainable than stainless steel IBC for cleaning based on water consumption and energy consumption, as well as, cost of capital expenditure. For project time and complexity, IBC project needs 22 to 30 weeks but FIBC project only needs 8 to 10 weeks.


After that she briefed flexible containment solutions optimized powder handling during chemical synthesis under API process train.


Finally, she introduced the concept of “Quality by Design (QbD)”. She said the DoverPac and D100 systems maintain closed charging minimizing the risk of contamination and particularly cross contamination in a shared facility.


Reference:

ILC Dover - https://www.ilcdover.com/

20220607: CAP Webinar: Improve Your Quality with CAP Inspector Knowledge and Deficiency Data - https://qualityalchemist.blogspot.com/2022/06/cap-webinar-improve-your-quality-with.html

20211118: STERIS WORKSHOP - A Risk Assessment Approach to Address Fungal Spore Contamination in a Cell and Gene Therapy Cleanroom - https://qualityalchemist.blogspot.com/2021/11/steris-workshop-risk-assessment.html

20211117: Regenerative Medicine 101 Webinar - Information for Patients, Caregivers & Advocates - https://qualityalchemist.blogspot.com/2021/11/regenerative-medicine-101-webinar.html

20161216: HKSTP 2nd Hong Kong & Guangzhou International Conference on Stem Cell and Regenerative Medicine - https://qualityalchemist.blogspot.com/2016/12/hkstp-2nd-hong-kong-guangzhou.html

20151220: HKSTP Hong Kong & Guangzhou International Conference on Stem Cell and Regenerative Medicine - https://qualityalchemist.blogspot.com/2015/12/hkstp-hong-kong-guangzhou-international.html

20140608: HKU Public Lecture on Gene and Cancer & Stem Cells - https://qualityalchemist.blogspot.com/2014/06/hku-public-lecture-on-gene-and-cancer.html


2022年6月18日星期六

OBORRI Webinar - Sanctions and Anti-sanctions: The Russian Case

Webinar named “Sanctions and Anti-sanctions: The Russian Case” was organized by One Belt One Road Research Institute (OBORRI), Chu Hai College of Higher Education on 18th Jun 2022. In the beginning, Prof. Oleksandr Rogach (Professor, One Belt One Road Research Institute, Chu Hai College & Taras Shevchenko National University of Kyiv, Ukraine) gave an opening speech and he introduce the topics’ background and guest speakers. 


The first speaker was Mr Ryan Chan Ming Tai (Deputy Director General, Silk Road Economic Development Research Center) and his topic entitled “General background of the sanctions imposed on Russia”.  Firstly, Mr. Chan stated the background such as the Office of Foreign Assets Control (OFAC) of the US Department of the Treasury which enforces economic and trade sanctions.


Then Mr. Chan briefed the scope of sanctions on Russia and history of USA’s sanctions since 2014 including energy sector, financial sector, military goods, mercenaries and transportation.


And then he mentioned the impacts on aviation industry and international companies (e.g. McDonald’s, Coca-Cola and Starbucks). Then he introduced Russia’s defense against global sanctions.


After that the Russia’s key role in energy exports, global supply chain and global food crisis were discussed.


Since Russia is lacking high-tech products domestically, Mr. Chan showed the diagram of high-tech goods in 2019 and found that Europe is dominated. However, China involvement is expected to increase.


Finally, Mr. Ryan Chan using global value chain to explain Russia’s involvement in the global economy. Europe and Central Asian countries are most dependent on Russia’s large exported metal products that not only oil and gas.


Lastly, the role of Russia in the global supply chain was explained and Russia would gradually shift its focus to Asia.  He concluded the short-terms impacts including hyperinflation on energy and food, as well as, lower economy growth in the Euro zone. The long-terms impacts were dramatic reorganization of the global economy; localization, regionalization and politicization of production chain and supply chain by higher geopolitical risk and a fragmentation of the trade system.


The second speaker was Prof. Oleksandr Pidchosa (Associate Professor, One Belt One Road Research Institute, Chu Hai College & Taras Shevchenko National University of Kyiv, Ukraine) and his topic named “Russian Economy Under Sanctions: Implications for the Financial Sector”.  Firstly, he showed western expected results in the beginning of the sanctions but it didn’t happen.


Then Prof. Pidchosa briefed some background of Russia historical experience and competence in circumventing sanctions and could trace back to USSR in 1918.  Then he introduced the structure of Russia’s GDP in 2021.


And then he stated the current condition of Russia’s Economy that the macroeconomic stability of the country was not significantly affected, as well as, low unemployment rate (4%). As a result of Western actions, confidence was broken in the Jamaica monetary system, the US dollar, the Euro and Western financial institutions.


After that Russia solved the cross-border payments using SFPS (System for Transfer of Financial Messages) and the Chinese CIPS (Cross-Border Interbank Payment System) since 2017.  Russia and Iran, India & other counties had agreed to use national currencies.  Blockchain technology would be employed to replace SWIFT and planned to use the digital ruble in 2023. 


Those cryptocurrencies (along with physical gold) were considered as one of the options for conducting financial transactions.  Moreover, a mechanism for circumventing “Gold sanctions” was also mentioned because of sanctions on LME in London, COMEX in New York and Switzerland.


The diagram showed the comparison on the effect of sanctions through Russia’s unfriendly countries and friendly countries.


Finally, he mentioned about Hong Kong situation on Russia trading cases. Lastly, Prof. Pidchosa concluded that “In general, the question is not about sanctions and counter-sanction in long-term perspective, but about those tectonic shifts and processes launched in the global economy.”

Reference:

OBORRI - https://www.chuhai.edu.hk/node/1794

20220505: OBORRI Webinar: International Economic Trends - Post Pandemic - https://qualityalchemist.blogspot.com/2022/05/oborri-webinar-international-economic.html

20190319: Chu Hai College Public Talk on Uzbekistan: On the Reform Path - https://qualityalchemist.blogspot.com/2019/03/chu-hai-college-public-talk-on.html



2022年6月17日星期五

HKCIE Technical Visit to Exhibition Centre

 The technical visit to Exhibition Centre Station (港鐵會展站) was organized by Hong Kong Chinese Institute of Engineers (HKCIE) (香港中國工程師學會) on 17th Jun 2022. Hong Kong Society for Quality (HKSQ) was one of co-organizers. Before visit, we took a group photo before enter the station.


We met some HKSQ members and took a photo for memory.


In the beginning, MTR representatives briefed some background of the station to us and then led us to visit this historical station.


Firstly, the representative introduced the design of the wall that is different images of same sea view taken in different time because the view was missed after station establishment.


Then he briefed some historical stories of different stations to us.


After that some improvement in the station was mentioned such as real time space condition demonstration.


Even in front of toilet, real time space engagement and air quality level were demonstrated.


The China Calligraphy of Exhibition Centre was drawn by one of retired engineer in MTR and this style would extend to other stations.


And then the construction method for cross harbor railway tunnel was introduced. The detail link named “MTR East Rail Line Cross-Harbour Extension – Construction Challenges” at http://www.mtrealstations.com/QR/exclp/05_en.html .


Finally, we visited the bombs which discovered at the station work site and took a group photo for memory.


Dr. Aaron Tong (Chairman, HKCIE) and I presented flag and anniversary book to MTR representatives.


We are appreciated to MTR gift and it is a very beautiful face mask.


Reference:

Hong Kong Chinese Institute of Engineers - http://www.hkcie.org/

HKSQ - http://www.hksq.org

20171007: HKCIE Visit to Liantang/Heung Yuen Wai Boundary Control Point Construction Site - https://qualityalchemist.blogspot.com/2017/10/hkcie-visit-to-liantangheung-yuen-wai.html

20160229: HKCIE Seminar on Extenics (可拓學) - https://qualityalchemist.blogspot.com/2016/02/hkcie-seminar-on-extenics.html


2022年6月16日星期四

ISO/TC 279 Innovation Management Virtual Meeting

The ISO/TC 279 Innovation Management Virtual Meeting was held on 16 Jun 2022. Almost all members and observers were joined the meeting online and the group photo was captured for memory.  Ms. Zhang Fan (China) and I (HKSAR) both joined the meeting.


Firstly, Ms. Pauline JORIS briefed the agenda in the beginning of the meeting. And then members were adopted it.


Mr. Johan CLAIRE (Chairman, ISO/TC 279) gave the presentation and declaration of intention on this technical committee. Firstly, he introduced his ISO journey since 2005.


After that he briefed the role of chairperson of a technical committee of ISO/TC 279.


Finally, Mr. Johan CLAIRE briefed the strategy business plan (SBP) and reviewed the current SBP.


Lastly, he briefed the development of ISO 56001 and expected to be completed in 2023 or 2024. 



2022年6月10日星期五

HKPC Webinar: Automated Business Continuity & Data Protection in Smart Manufacturing

Webinar named “Automated Business Continuity & Data Protection in Smart Manufacturing” was organized by HKPC on 10th Jun 2022. They invited two speakers to introduce cyber resilience and the first rule of business continuity. 


The first speaker was Mr. Lawrence Law (Security Consultant, HKCERT) and his topic entitled “Embracing Cyber Resilience in Smart Manufacturing”. Firstly, he introduced HKCERT that coordination of information security incident response for local enterprises and internet users.  He also briefed the global operational technology (OT) security incidents increasing in manufacturing segment.


Then Mr. Law explained four factors causing OT sectors’ vulnerability. They are “Human Operated Ransomware”, “Pandemic drives”, “Digital Transformation” and “Unpatched Systems”. Most of hacker attack IT first and then went to OT that cause Industrial control system (ICS) vulnerability.


After that he mentioned to build cyber resilience withstands cyber-attacks. 3 key strategies are “Adopt Network Segmentation”, “Data Backup and Recovery” and “Enhance Network Security Visibility”. For segmenting OT network, De-militarized Zone (DMZ) was employed to separate IT and OT.


The Purdue Model, formally the Purdue Enterprise Reference Architecture (PERA), is a structural model for industrial control system (ICS) security, concerning physical processes, sensors, supervisory controls, operations, and logistics. It separated from Level 0 to Level 5. Some critical data stored in level 3 under OT and level 4 under IT.


Finally, Mr. Law stated implementation of network security through “enforcement of strict access control to OT network”, “establishment of visibility to all OT communication”, “Conducting baseline of device asset and setting” and “On-going monitoring and detection”. Lastly he introduced IoT security best practice guideline in HKCERT website.


The second speaker was Mr. Chris Wong (Regional Channel System Engineer, HK & Taiwan, Veeam).  In the beginning, he introduced the history of ransomware since 1981.


Then he briefed Advanced Ransomware Attach in six stages and they are “Observation”, “Setting up Shop”, “Preparation”, “Cripple recoverability” and “Ransom Declared”.


After that Mr. Wong introduced three-part defense approach and they are protection of immutable backup, alert for visibility and reliable recovery.


Finally, he suggested 32110 best practices for ransomware protection. An immutable backup should be employed for protecting data that ensures the data is fixed, unchangeable, and can never be deleted, encrypted, or modified. Recovery should consider Scale, Recure Restore and Disaster Recovery Orchestration.


Reference:

HKPC - https://www.hkpc.org/en

20201111: HKPC SME Index Conference – SenseTime AI Sharing - https://qualityalchemist.blogspot.com/2020/11/hkpc-sme-index-conference-sensetime-ai.html

20201009: HKPC Webinar - How Machine Learning & AI work in Robotic Process Automation (RPA) - https://qualityalchemist.blogspot.com/2020/10/hkpc-webinar-how-machine-learning-ai.html

20190930: HKPC AI & 5G Workshop: Alibaba Damo Academy and Huawei (阿里巴巴達摩院及華為工作坊) - https://qualityalchemist.blogspot.com/2019/09/hkpc-ai-5g-workshop-alibaba-damo.html

20190617: HKPC AI Impulse 2019 Summit - Day 1 - https://qualityalchemist.blogspot.com/2019/06/hkpc-ai-impulse-2019-summit-day-1.html

20190618: HKPC AI Impulse 2019 Summit - Day 2 - https://qualityalchemist.blogspot.com/2019/06/hkpc-ai-impulse-2019-summit-day-2.html


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