CityU HKIAS Distinguished Lecture - Single Cell Analysis of Tumor Heterogeneity During Cancer Metastasis

The HKIAS Distinguished Lecture named “Single Cell Analysis of Tumor Heterogeneity During Cancer Metastasis” was held on 18^th Feb 2022 in online mode. Prof. Michael Yang (Department of Biomedical Sciences, CityU) was the guest speaker. In the beginning, he introduced his research interests including biochip technology, nanomedicine and cancer biology.  He also introduced his book named “Detection Methods in Precision Medicine” in 2020. 

Firstly, he briefed the background of cancer metastasis and its key steps involved invasion, intravasation, circulation, extravasation and colonization. He said understanding the dynamics of this process will help identify targets for molecular therapies that may halt or possibly reverse cancer growth and metastasis.

Then Prof. Yang mentioned two research challenges in this field and they were “Tumor Heterogeneity” and “Microenvironment”.

Chemotasix/Electrotaxis plays an important role during embryogenesis, inflammation, wound healing and tumour metastasis.  Therefore, Prof. Yang’s team employed microfluidics with gradient control and microchannels for studying single cell migration under different physical and biological conditions.

After that he briefed the background of Epithelial-Mesenchymal Transition (EMT) that occurs through either single-cell dissemination or collective migration. Finally, Prof. Yang shared some data analysis which related to tumor heterogeneity in different microenvironment.

Lastly, Circulating Tumor Cells (CTC) biological and physical properties studies were discussed such as CTC enrichment and isolation.

Prof. Yang expected to win the war on cancer through collaboration with all scholars and experts at the end of seminar.

Reference:

HKIAS - https://www.hkias.cityu.edu.hk/en/

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