2024年4月26日星期五

PolyU FS Chair Professor Lecture on Opportunities and Challenges for Translating Natural Products into New Drugs

The PolyU Faculty of Science (FS) Chair Professor Inaugural Lecture named “Opportunities and Challenges for Translating Natural Products into New Drugs” was organized by Faculty of Science, PolyU on 26 Apr 2024. Before the lecture, I took photo with Prof. Simon Lee (Chair Professor of Biomedical Sciences). 


I also met Dr. Ka-Sing Leung (Adjunct Associate Professor (Food Science and Safety), ABCT Dept)


Prof. Lee’s PhD supervisor Prof. Kwok Pui FUNG (CUHK) also attended and took a photo for memory.


In the beginning, Prof. Simon Lee introduced the “Compendium of Materia Medica” and Chen Pi as traditional food for curing phlegm and cough. And he also stated some studies on Chen Pi employing zebra fish model. His talk topics included “Role of alpha-synuclein and mitochondria in neurodegeneration”, “Zebrafish screen”, “Potential first-in-class neuroprotective drug candidate”, “Biomimetic drug delivery” and “Bioactive natural peptide”.


And then he mentioned some neurodegenerative diseases such as Parkinson’s disease (PD) that is currently no disease modifying drugs. 


Prof. Simon Lee briefed the mechanism of Parkin interaction that loss of mitochondrial potential. He stated Mitostasis in Neurons that maintaining Mitochondria in an extended cellular architecture. (Energy recovered regain regeneration)


And then he showed the imaging mitochondria using zebrafish. It could be employed for pre-clinical drug discovery and development. 


He then quoted a paper named “A chemical genetic screen for cell cycle inhibitors in zebrafish embryos” (Chem Biol Drug Des 2006, 68: 213-219) and described different applications.


After that he introduced his paper named “Studying the time course of cardiac responses of the same zebrafish using scalable fish-dock microarchitecture” using test automation plus big data to develop a new generation of microfluidic chip for automated zebrafish assay.


The key message of zebrafish screen was discussed.


He also studied the medicinal coral based on traditional use in TCM.


Finally, he introduced his student and quoted the paper named “A new invertebrate NPY-like polypeptide, ZoaNPY, from the Zoanthus sociatus, as a novel ligand of human NPY Y2 receptor rescues vascular insufficiency via PLC/PKC and Src- FAK-dependent signaling pathways” (Pharmacol Res. 2024 Apr 3:203:107173)


Lastly, he showed some scientific activities to introduce zebrafish test to general public in Macau.


At the end, we got a souvenir zebrafish doll and took a photo with Dr. Kelvin Mui (IP Manager, RIO) and Prof. Simon Lee.

Reference

Faculty of Science (FS), PolyU - https://www.polyu.edu.hk/fs/

FS Chair Professor Inaugural Lecture - Prof. Simon Ming Yuen LEE - https://www.polyu.edu.hk/fs/news-and-events/events/2024/4/fs-chair-professor-inaugural-lecture_prof-simon-ming-yuen-lee/

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