The PolyU Faculty of Science (FS) Chair Professor Inaugural
Lecture named “Opportunities and Challenges for Translating Natural Products
into New Drugs” was organized by Faculty of Science, PolyU on 26 Apr 2024. Before
the lecture, I took photo with Prof. Simon Lee (Chair Professor of Biomedical
Sciences).
I also met Dr. Ka-Sing Leung (Adjunct Associate
Professor (Food Science and Safety), ABCT Dept)
Prof. Lee’s PhD supervisor Prof. Kwok Pui FUNG (CUHK)
also attended and took a photo for memory.
In the beginning, Prof. Simon Lee introduced the “Compendium
of Materia Medica” and Chen Pi as traditional food for curing phlegm and cough.
And he also stated some studies on Chen Pi employing zebra fish model. His talk
topics included “Role of alpha-synuclein and mitochondria in neurodegeneration”,
“Zebrafish screen”, “Potential first-in-class neuroprotective drug candidate”, “Biomimetic
drug delivery” and “Bioactive natural peptide”.
And then he mentioned some neurodegenerative diseases
such as Parkinson’s disease (PD) that is currently no disease modifying drugs.
Prof. Simon Lee briefed the mechanism of Parkin
interaction that loss of mitochondrial potential. He stated Mitostasis in
Neurons that maintaining Mitochondria in an extended cellular architecture.
(Energy recovered regain regeneration)
And then he showed the imaging mitochondria using
zebrafish. It could be employed for pre-clinical drug discovery and development.
He then quoted a paper named “A chemical genetic screen
for cell cycle inhibitors in zebrafish embryos” (Chem Biol Drug Des 2006, 68:
213-219) and described different applications.
After that he introduced his paper named “Studying the
time course of cardiac responses of the same zebrafish using scalable fish-dock
microarchitecture” using test automation plus big data to develop a new
generation of microfluidic chip for automated zebrafish assay.
The key message of zebrafish screen was discussed.
He also studied the medicinal coral based on
traditional use in TCM.
Finally, he introduced his student and quoted the
paper named “A new invertebrate NPY-like polypeptide, ZoaNPY, from the Zoanthus
sociatus, as a novel ligand of human NPY Y2 receptor rescues vascular
insufficiency via PLC/PKC and Src- FAK-dependent signaling pathways” (Pharmacol
Res. 2024 Apr 3:203:107173)
Lastly, he showed some scientific activities to
introduce zebrafish test to general public in Macau.
At the end, we got a souvenir zebrafish doll and took
a photo with Dr. Kelvin Mui (IP Manager, RIO) and Prof. Simon Lee.
Reference
Faculty of Science (FS), PolyU - https://www.polyu.edu.hk/fs/
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